G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches.

@article{Vischer2015GPR,
  title={G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches.},
  author={Henry F. Vischer and Mari{\'a}n Castro and J. -P. Pin},
  journal={Molecular pharmacology},
  year={2015},
  volume={88 3},
  pages={
          561-71
        }
}
Heteromerization of G protein-coupled receptors (GPCRs) can significantly change the functional properties of involved receptors. Various biochemical and biophysical methodologies have been developed in the last two decades to identify and functionally evaluate GPCR heteromers in heterologous cells, with recent approaches focusing on GPCR complex stoichiometry and stability. Yet validation of these observations in native tissues is still lagging behind for the majority of GPCR heteromers… CONTINUE READING
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