G-CSFR Ubiquitination Critically Regulates Myeloid Cell Survival and Proliferation

@article{Ai2008GCSFRUC,
  title={G-CSFR Ubiquitination Critically Regulates Myeloid Cell Survival and Proliferation},
  author={Jing Ai and Lawrence J. Druhan and Megan J. Loveland and Belinda R. Avalos},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={2791 - 2808}
}
The granulocyte colony-stimulating factor receptor (G-CSFR) is a critical regulator of granulopoiesis. Mutations in the G-CSFR in patients with severe congenital neutropenia (SCN) transforming to acute myelogenous leukemia (AML) have been shown to induce hypersensitivity and enhanced growth responses to G-CSF. Recent studies have demonstrated the importance… CONTINUE READING