G-CSF serum pharmacokinetics during peripheral blood progenitor cell mobilization: neutrophil count-adjusted dosage might potentially improve mobilization and be more cost-effective

@article{Faulkner1998GCSFSP,
  title={G-CSF serum pharmacokinetics during peripheral blood progenitor cell mobilization: neutrophil count-adjusted dosage might potentially improve mobilization and be more cost-effective},
  author={L B Faulkner and Fabio Tucci and Angela Tamburini and Veronica Tintori and A A Lippi and Franco Bambi and F Malentacca and Chiara Azzari and A M Gelli and Filippo Genovese and Gabriella Bernini},
  journal={Bone Marrow Transplantation},
  year={1998},
  volume={21},
  pages={1091-1095}
}
The optimal dosing schedule of G-CSF for peripheral blood progenitor cell (PBPC) mobilization is still under investigation although many centers use 10 μg/kg/day in a single subcutaneous dose. However, G-CSF clearance increases with increasing absolute neutrophil count (ANC). Hence a G-CSF dosage adjusted to ANC might be a reasonable approach. We measured G… CONTINUE READING