G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome.

@article{Aggarwal2000GCSFAI,
  title={G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome.},
  author={Amita P Aggarwal and Christopher S. R. Baker and Timothy W. Evans and Patricia L. Haslam},
  journal={The European respiratory journal},
  year={2000},
  volume={15 5},
  pages={895-901}
}
Activated neutrophils play a major role in the pathogenesis of acute respiratory distress syndrome (ARDS), and persistence of pulmonary neutrophilia is related to poor survival. Interleukin (IL)-8 is implicated in recruiting neutrophils to the lungs but it has been postulated that granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), which can promote the survival of neutrophils by delaying apoptosis, may prolong the inflammatory response… CONTINUE READING

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Guidelines for measurement of acellular components and recommendations for standardization of bronchoalveolar lavage (BAL) Report of the European Respiratory Society Task Force

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