G-CSF and GM-CSF in Neutropenia.

  title={G-CSF and GM-CSF in Neutropenia.},
  author={Hrishikesh M. Mehta and Michael Malandra and Seth J Corey},
  journal={Journal of immunology},
  volume={195 4},
G-CSF and GM-CSF are used widely to promote the production of granulocytes or APCs. The U.S. Food and Drug Administration approved G-CSF (filgrastim) for the treatment of congenital and acquired neutropenias and for mobilization of peripheral hematopoietic progenitor cells for stem cell transplantation. A polyethylene glycol-modified form of G-CSF is approved for the treatment of neutropenias. Clinically significant neutropenia, rendering an individual immunocompromised, occurs when their… CONTINUE READING

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