G-Alpha Subunit Abundance and Activity Differentially Regulate β-Catenin Signaling

  title={G-Alpha Subunit Abundance and Activity Differentially Regulate β-Catenin Signaling},
  author={Arshiya Banu and Karen J Liu and Alistair J Lax and Agamemnon E. Grigoriadis},
  booktitle={Molecular and cellular biology},
Heterotrimeric G proteins are signal transduction proteins involved in regulating numerous signaling events. In particular, previous studies have demonstrated a role for G-proteins in regulating β-catenin signaling. However, the link between G-proteins and β-catenin signaling is controversial and appears to depend on G-protein specificity. We describe a detailed analysis of a link between specific G-alpha subunits and β-catenin using G-alpha subunit genetic knockout and knockdown approaches… CONTINUE READING

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Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins.

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  • 2013