G-765C COX-2 gene promoter polymorphism and risk of atherosclerosis after kidney transplantation.

@article{Courivaud2009G765CCG,
  title={G-765C COX-2 gene promoter polymorphism and risk of atherosclerosis after kidney transplantation.},
  author={C{\'e}cile Courivaud and Jamal Bamoulid and Pierre Tiberghien and Philippe Saas and Marc Chalopin and Didier Ducloux and C. Legendre and Eric Thervet},
  journal={Transplantation},
  year={2009},
  volume={88 6},
  pages={
          851-2
        }
}
Renal transplant recipients have disproportionately high rates of atherosclerotic outcomes. Although traditional cardiovascular risk factors are frequent in this population, our group has emphasized the importance of inflammatory processes in the atherogenesis after renal transplantation (1). It has been proposed that COX-2-mediated prostaglandin (PG) production by activated macrophages may promote atherosclerosis through a number of mechanisms (2). A functional G3C polymorphism has been… CONTINUE READING
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