G 541 R within the 4070 A TM Protein Regulates Fusion in Murine Leukemia Viruses

@inproceedings{OReilly2003G5R,
  title={G 541 R within the 4070 A TM Protein Regulates Fusion in Murine Leukemia Viruses},
  author={Lucille O’Reilly and Monica J Roth},
  year={2003}
}
The mutation G541R within the ectodomain of TM was isolated in three independent chimeric enveloped murine leukemia virus (MuLV) viral populations originally impaired in viral passage and in wild-type 4070A. Isolation of G541R in multiple populations suggested it played a critical role in viral envelope function. Using a viral vector system, the observed effects of the G541R mutation within MuLV envelope proteins were pleiotropic and included effects on the regulation of SU-TM interactions and… CONTINUE READING
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