G-33A mutation in the promoter region of thrombomodulin gene and its association with coronary artery disease and plasma soluble thrombomodulin levels.

@article{Li2000G33AMI,
  title={G-33A mutation in the promoter region of thrombomodulin gene and its association with coronary artery disease and plasma soluble thrombomodulin levels.},
  author={Y H Li and Jia-Hong Chen and H Laura Wu and Gaocai Shi and Hsin Chieh Huang and Ting-Hsing Chao and Wen Chan Tsai and L M Tsai and How Ran Guo and William S. Wu and Z C Chen},
  journal={The American journal of cardiology},
  year={2000},
  volume={85 1},
  pages={8-12}
}
Thrombomodulin is an endothelial glycoprotein that decreases thrombin activity and activates protein C. A recent study has shown that G-33A promoter mutation of the thrombomodulin gene occurs particularly in Asians. In this study, we analyzed the distribution of G-33A mutation in the promoter region of the thrombomodulin gene in the Chinese population and determined whether the mutation might be a risk for coronary artery disease (CAD). In addition, the influence of this mutation on plasma… CONTINUE READING

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