G 2 arrest in Xenopus oocytes depends on phosphorylation of cdc 25 by protein kinase A

@inproceedings{Duckworth2002G2A,
  title={G 2 arrest in Xenopus oocytes depends on phosphorylation of cdc 25 by protein kinase A},
  author={Brian C. Duckworth and Jennifer S. Weaver and Joan V. Ruderman},
  year={2002}
}
Xenopus oocytes, which are arrested in G2 of meiosis I, contain complexes of cyclin B–cdc2 (M phase-promoting factor) that are kept repressed by inhibitory phosphorylations on cdc2 at Thr-14 and Tyr-15. Progesterone induces a cytoplasmic signaling pathway that leads to activation of cdc25, the phosphatase that removes these phosphorylations, catalyzing entry into M phase. It has been known for 25 years that high levels of cAMP and protein kinase A (PKA) are required to maintain the G2 arrest… CONTINUE READING

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Development (Cambridge, U.K

M. Peter, J. C. Labbe, M. Doree, E. Mandart
2002

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