G 1 Cell Cycle Arrest and Apoptosis Are Induced in NIH 3 T 3 Cells by KN-93 , an Inhibitor of CaMK-lI ( the Multifunctional Ca 2 / CaM Kinase ) 1

@inproceedings{Robert2005G1C,
  title={G 1 Cell Cycle Arrest and Apoptosis Are Induced in NIH 3 T 3 Cells by KN-93 , an Inhibitor of CaMK-lI ( the Multifunctional Ca 2 / CaM Kinase ) 1},
  author={L Robert and M.. and Tombes and Bill Steven and Grant and {\'E}ric and H.. and Westin and Geoffrey and Krystal},
  year={2005}
}
Abstrad CaMK-II (the type II multifundional Ca2’/calmodulin kinase) is a ubiquitous serine/threonine protein kinase that is adivated by Ca2 and calmodulin (CaM) and has been implicated in cell cycle control. NIH 3T3 fibroblast cytosolic extrads contain CaMK-lI enzymatic adivity and two major Ca2 /CaM-dependent phosphoproteins of Mr 55,000 and 1 1 5,000. Reverse transcription-PCR indicates that the ‘y and Ic isozymes of CaMK-Il are predominately expressed. KN-93, a novel membranepermeant… CONTINUE READING
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