Corpus ID: 36960054

G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.

  title={G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.},
  author={Ye Chen-Izu and Rui-ping Xiao and Leighton T Izu and H. Cheng and Meike Kuschel and Harold A. Spurgeon and Edward G. Lakatta},
  journal={Biophysical journal},
  volume={79 5},
A plausible determinant of the specificity of receptor signaling is the cellular compartment over which the signal is broadcast. In rat heart, stimulation of beta(1)-adrenergic receptor (beta(1)-AR), coupled to G(s)-protein, or beta(2)-AR, coupled to G(s)- and G(i)-proteins, both increase L-type Ca(2+) current, causing enhanced contractile strength. But only beta(1)-AR stimulation increases the phosphorylation of phospholamban, troponin-I, and C-protein, causing accelerated muscle relaxation… Expand
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  • R. Xiao
  • Biology, Medicine
  • Circulation research
  • 2000
A solid study is presented that provides additional evidence supporting a dual G protein coupling for β2AR and extended the previous finding to several other Gs-coupled receptors in human heart. Expand
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  • Biology, Medicine
  • Science Signaling
  • 2010
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