G‐protein‐coupled receptor expression, function, and signaling in macrophages

@article{Lattin2007GproteincoupledRE,
  title={G‐protein‐coupled receptor expression, function, and signaling in macrophages},
  author={Jane E. Lattin and David A. Zidar and Kate Schroder and Stuart Kellie and David A. Hume and Matthew J. Sweet},
  journal={Journal of Leukocyte Biology},
  year={2007},
  volume={82}
}
G‐protein‐coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage‐restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which… 
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120 Citations

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Emerging Roles for G-protein Coupled Receptors in Development and Activation of Macrophages

New insights into macrophage biology, differences of human, and mouse macrophages are summarized and details of some of the GPCRs expressed by this cell type are given.

Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach.

Recent research advances in the identification of novel GPCRs and their protein interactions are reviewed.

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.

G Protein-Coupled Receptors in Macrophages.

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Metabolic Functions of G Protein-Coupled Receptors and β-Arrestin-Mediated Signaling Pathways in the Pathophysiology of Type 2 Diabetes and Obesity

The physiological outcome of activating a certain GPCR in a particular tissue may also be modulated by β-arrestin-dependent, but G protein-independent signaling pathways, so that the development of obesity and T2D-related metabolic disorders is targeted.

Ligation of the adhesion‐GPCR EMR2 regulates human neutrophil function

  • S. YonaHsi-Hsien Lin M. Stacey
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
This work demonstrates how the human‐restricted adhesion‐GPCR, EMR2 (epidermal growth factor‐like module‐containing mucin‐like hormone receptor), regulates neutrophil responses by potentiating the effects of a number of proinflamma‐tory mediators and shows that the transmembrane region is critical for adhesion-GPCRs function.

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

The constitutive or regulated expression in macrophages of several GPCRs identified in this study has not previously been described and are likely to provide important insights into macrophage biology, as well as novel inflammatory pathways that could be future targets for drug discovery.

G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity

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Special Topic: NF-κB, Immunity and Cancer G Protein–Coupled Receptor Connectivity to NF-κB in Inflammation and Cancer

A clear understanding of network interactions between GPCR signaling pathways and those that control NF-kB may be valuable for the development of better drugs and drug combinations.
...

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