G‐protein‐coupled receptor expression, function, and signaling in macrophages

  title={G‐protein‐coupled receptor expression, function, and signaling in macrophages},
  author={Jane E. Lattin and David A. Zidar and Kate Schroder and Stuart Kellie and David A. Hume and Matthew J. Sweet},
  journal={Journal of Leukocyte Biology},
G‐protein‐coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage‐restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which… 

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  • S. YonaHsi-Hsien Lin M. Stacey
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
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