Gγ13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium

@article{Huang1999G13CW,
  title={G$\gamma$13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium},
  author={Liquan Huang and Y. Gopi Shanker and Jolanta Dubauskaite and Jenny Z. Zheng and Wen-tao Yan and Sophia Rosenzweig and Andrew I Spielman and Marianna Max and Robert F. Margolskee},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={1055-1062}
}
Gustducin is a transducin-like G protein selectively expressed in taste receptor cells. The α subunit of gustducin (α-gustducin) is critical for transduction of responses to bitter or sweet compounds. We identified a G-protein γ subunit (Gγ13) that colocalized with α-gustducin in taste receptor cells. Of 19 α-gustducin/Gγ13-positive taste receptor cells profiled, all expressed the G protein β3 subunit (Gβ3); ~80% also expressed Gβ1. Gustducin heterotrimers (α-gustducin/Gβ1/Gγ13) were activated… 
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