Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.

@article{Khan2015G41AA,
  title={Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.},
  author={Shahriar M. Khan and Adam Min and Sarah Gora and Geeda M Houranieh and Rhiannon Campden and M{\'e}lanie Robitaille and Phan Trieu and Darlaine P{\'e}trin and Ashley M. Jacobi and Mark A. Behlke and St{\'e}phane Angers and Terence E. H{\'e}bert},
  journal={Cellular signalling},
  year={2015},
  volume={27 8},
  pages={1597-608}
}
Much is known about the how Gβγ subunits regulate effectors in response to G protein-coupled receptor stimulation. However, there is still a lot we don't know about how specific combinations of Gβ and Gγ are wired into different signalling pathways. Here, using an siRNA screen for different Gβ and Gγ subunits, we examined an endogenous M3 muscarinic… CONTINUE READING