Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity.

@article{Xu2012GSC,
  title={Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity.},
  author={Hui Xu and Elena Kardash and Songhai Chen and Erez Raz and Fang Lin},
  journal={Development},
  year={2012},
  volume={139 1},
  pages={57-62}
}
During development, primordial germ cells (PGCs) migrate from the sites of their specification towards the region in which the future gonad develops. This cell migration requires polarization of PGCs and their responsiveness to external guidance cues. In zebrafish, the directed migration and polarization of PGCs are regulated independently, by the chemokine Cxcl12a and the Rho GTPase Rac1, respectively. However, the upstream signals controlling Rac activity in this context have not yet been… CONTINUE READING
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