Gβγ and the C Terminus of SNAP-25 Are Necessary for Long-Term Depression of Transmitter Release

@inproceedings{Zhang2011GAT,
  title={Gβγ and the C Terminus of SNAP-25 Are Necessary for Long-Term Depression of Transmitter Release},
  author={Xiao-lei Zhang and Chirag Upreti and Patric K. Stanton},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Short-term presynaptic inhibition mediated by G protein-coupled receptors involves a direct interaction between G proteins and the vesicle release machinery. Recent studies implicate the C terminus of the vesicle-associated protein SNAP-25 as a molecular binding target of Gβγ that transiently reduces vesicular release. However, it is not known whether SNAP-25 is a target for molecular modifications expressing long-term changes in transmitter release probability. METHODOLOGY… CONTINUE READING