Gαq-coupled Receptor Internalization Specifically Induced by Gαq Signaling REGULATION BY EBP50

@inproceedings{Rochdi2003GqcoupledRI,
  title={Gαq-coupled Receptor Internalization Specifically Induced by Gαq Signaling REGULATION BY EBP50},
  author={Moulay Driss Rochdi and Jean-Luc Parent},
  year={2003}
}
Abstract In the present report, we investigated the effect of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) expression on the agonist-induced internalization of the thromboxane A2 β receptor (TPβ receptor). Interestingly, we found that EBP50 almost completely blocked TPβ receptor internalization, which could not be reversed by overexpression of G protein-coupled receptor (GPCR) kinases and arrestins. Because we recently demonstrated that EBP50 can bind to and inhibit Gαq, we next… CONTINUE READING

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