Gα13 mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells

@article{Postma2001G13MA,
  title={Gα13 mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells},
  author={Friso R. Postma and Kees Jalink and Trudi Hengeveld and Stefan Offermanns and Wouter H Moolenaar},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={121-124}
}
Loss of membrane potential (membrane depolarization) is one of the earliest and most striking responses of quiescent cells to stimulation with serum or G protein-coupled receptor (GPCR) agonists such as lysophosphatidic acid and thrombin. Membrane depolarization is due to the activation of a chloride conductance. While this response has received relatively little attention in the past, it is clear that the acute loss of membrane potential may have important physiological consequences. However… CONTINUE READING
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