Gα12 and Gα13 Interact with Ser/Thr Protein Phosphatase Type 5 and Stimulate Its Phosphatase Activity

  title={Gα12 and Gα13 Interact with Ser/Thr Protein Phosphatase Type 5 and Stimulate Its Phosphatase Activity},
  author={Yoshiaki Yamaguchi and H. Katoh and K. Mori and M. Negishi},
  journal={Current Biology},
  • Yoshiaki Yamaguchi, H. Katoh, +1 author M. Negishi
  • Published 2002
  • Biology
  • Current Biology
  • Abstract The Gα subunits of the G 12 family of heterotrimeric G proteins, defined by Gα 12 and Gα 13 , are involved in many signaling pathways and diverse cellular functions [1]. In an attempt to elucidate downstream effectors of Gα 12 for cellular functions, we have performed a yeast two-hybrid screening of a rat brain cDNA library and revealed that Ser/Thr protein phosphatase type 5 (PP5) is a novel effector of Gα 12 and Gα 13 . PP5 is a newly identified phosphatase and consists of a C… CONTINUE READING
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