Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart.


AIMS Regulator of G protein signalling (RGS) proteins act as molecular 'off switches' that terminate G protein signalling by catalyzing the hydrolysis of Gα-bound GTP to GDP. Many different Gα(i)-coupled receptors have been implicated in the cardioprotective effects of ischaemic preconditioning. However, the role of RGS proteins in modulating… (More)
DOI: 10.1093/cvr/cvr054


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