Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.

@article{Behrens1999G6I,
  title={G{\"o} 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.},
  author={M Margarita Behrens and Uta Strasser and Dennis W. Choi},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 3},
  pages={919-24}
}
We report here that addition of the protein kinase C inhibitor Gö 6976 blocked neurotrophin-induced signaling and autophosphorylation of neurotrophin-specific tyrosine kinase (Trk) receptors, either Trk B in cortical neurons or Trk A in GT1-1-trk9 cells. The effect of Gö 6976 on Trk autophosphorylation was not inhibited by 100 microM orthovanadate, suggesting that the block was not due to the activation of tyrosine phosphatases. Moreover, addition of 10-100 nM concentrations of Gö 6976… CONTINUE READING
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