Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.

@article{Tse2013FynRA,
  title={Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.},
  author={Margaret Chui Ling Tse and Xia Liu and Seran Yang and Keqiang Ye and C B Chan},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 9},
  pages={
          1797-808
        }
}
Fyn is a tyrosine kinase with multiple roles in a variety of cellular processes. Here we report that Fyn is a new kinase involved in adipocyte differentiation. Elevated Fyn protein is detected specifically in the adipocytes of obese mice. Moreover, Fyn expression increases progressively in 3T3-L1 cells during in vitro adipogenesis, which correlates with its kinase activity. Inhibition of Fyn by either genetic or pharmacological manipulation restrains the 3T3-L1 preadipocytes from fully… CONTINUE READING
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