Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis.

@article{GarciaRudaz2007FxnaAN,
  title={Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis.},
  author={Cecilia Garcia-Rudaz and F{\'e}lix Gasc{\'o}n Luna and Ver{\'o}nica Patricia Aguilar Tapia and Bredford Kerr and Lois M. A. Colgin and Francesco Galimi and Gregory A. Dissen and Neil D. Rawlings and Sergio R. Ojeda},
  journal={Development},
  year={2007},
  volume={134 5},
  pages={
          945-57
        }
}
In rodents, the formation of ovarian follicles occurs after birth. In recent years, several factors required for follicular assembly and the growth of the newly formed follicles have been identified. We now describe a novel gene, Fxna, identified by differential display in the neonatal rat ovary. Fxna encodes an mRNA of 5.4 kb, and a protein of 898 amino acids. Fxna is a transmembrane metallopeptidase from family M28, localized to the endoplasmic reticulum. In the ovary, Fxna mRNA is expressed… CONTINUE READING

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