Fuzzy complexes: a more stochastic view of protein function.

@article{Fuxreiter2012FuzzyCA,
  title={Fuzzy complexes: a more stochastic view of protein function.},
  author={M{\'o}nika Fuxreiter and Peter Tompa},
  journal={Advances in experimental medicine and biology},
  year={2012},
  volume={725},
  pages={1-14}
}
Intrinsically disordered proteins (IDPs) are widespread in eukaryotic proteomes and challenge the classical structure-function paradigm that equates a folded 3-D structure with protein function. However, IDPs often function by molecular recognition, in which they bind a partner molecule and undergo "induced folding" or "disorder-to-order transition" upon binding, which apparently suggests that in a functional context IDPs become ordered. Whereas this observation would restore the "prestige" of… CONTINUE READING
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