Fuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells.

@article{Gao2015FuzhisanAC,
  title={Fuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells.},
  author={Ran Gao and Ye Wang and Qingge Pan and Gaoya Huang and Nan Li and Jing Mou and Desheng Wang},
  journal={International journal of clinical and experimental medicine},
  year={2015},
  volume={8 5},
  pages={7231-40}
}
The accumulation of β-amyloid (Aβ) peptide plaques is the major pathogenic event in Alzheimer's disease (AD). Because β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) cleaves APP at the first amino acid of the Aβ domain and is the rate-limiting enzyme for Aβ peptide generation, the level of this aspartic protease is a focus of AD research… CONTINUE READING