Future technology insight: mass spectrometry imaging as a tool in drug research and development.

@article{Cobice2015FutureTI,
  title={Future technology insight: mass spectrometry imaging as a tool in drug research and development.},
  author={D F Cobice and Richard J. A. Goodwin and Per E. Andr{\'e}n and Anna Nilsson and C Logan Mackay and Ruth Andrew},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 13},
  pages={3266-83}
}
In pharmaceutical research, understanding the biodistribution, accumulation and metabolism of drugs in tissue plays a key role during drug discovery and development. In particular, information regarding pharmacokinetics, pharmacodynamics and transport properties of compounds in tissues is crucial during early screening. Historically, the abundance and distribution of drugs have been assessed by well-established techniques such as quantitative whole-body autoradiography (WBA) or tissue… CONTINUE READING
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