Future opportunities in preventing cisplatin induced ototoxicity.

  title={Future opportunities in preventing cisplatin induced ototoxicity.},
  author={Joost Huibert van den Berg and Jos H. Beijnen and Alfons J. M. Balm and Jan H. M. Schellens},
  journal={Cancer treatment reviews},
  volume={32 5},
Cisplatin is one of the most commonly used cytotoxic agents. Ototoxicity is an important and dose-limiting side-effect of cisplatin therapy. It is believed that cisplatin suppresses the formation of endogenous anti-oxidants that normally prevent the inner ear against reactive oxygen species (ROS). These ROS affect the outer hair cells (OHCs) in the organ of Corti. Results from clinical trials with amifostine, an anti-oxidant with possible otoprotective action during cisplatin therapy, were… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 32 extracted citations

The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity

Journal of the Association for Research in Otolaryngology • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…