Future directions in folding: the multi-state nature of protein structure.

Abstract

All possible protein folding intermediates exist in equilibrium with the native protein at native as well as non-native conditions, with occupation determined by their free energy level. The study of these forms can illuminate the fundamental principles of protein structure and folding. Hydrogen exchange methods can be used to detect and characterize these… (More)

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Cite this paper

@article{Bai1996FutureDI, title={Future directions in folding: the multi-state nature of protein structure.}, author={Yawen Bai and S. Walter Englander}, journal={Proteins}, year={1996}, volume={24 2}, pages={145-51} }