Future contributions on genetics

  title={Future contributions on genetics},
  author={M. Krebs},
  journal={The World Journal of Biological Psychiatry},
  pages={49 - 55}
  • M. Krebs
  • Published 2005
  • Psychology, Medicine
  • The World Journal of Biological Psychiatry
It has become obvious from epidemiological studies in families of patients affected or from twin studies, that most psychiatric disorders are in part genetically determined. Genetics have raised incredible hopes that the complex nature of psychiatric disorders might be unravelled. However, progress in psychiatry genetics have met major difficulties that have hampered psychiatry taking advantage of the new technologies as compared to other fields, such as neurology. In this non-exhaustive review… Expand
Interactions gènes/environnement dans la schizophrénie
(1) INSERM U796 Physiopathologie des Maladies Psychiatriques, Universite Paris Descartes, Service Hospitalo-Universitaire, Centre Hospitalier Sainte-Anne, Paris, France. Un facteur genetique estExpand
Troubles psychiatriques, génétique ou environnement : vers la fin du débat ?
Bien que les donnees d’epidemiologie aient clairement montre l’agregation des principaux troubles psychiatriques au sein de certaines familles, l’identification des genes impliques se heurte a leurExpand


Schizophrenia: a review of genetic studies.
The development and utilization of stringent, reliable diagnostic criteria, together with the advent of modern family, twin, and adoption paradigms, demonstrate the importance of genetic factors in understanding the familial basis of the disorder. Expand
Search for schizophrenia susceptibility genes
  • A. Pulver
  • Medicine, Biology
  • Biological Psychiatry
  • 2000
Patterns have emerged that focus research efforts on chromosomes 13, 8, 22, and 6 and 10, and initial heterogeneity analyses suggests that identifiable subgroups of the families may not contribute equally to these linkage findings. Expand
Bipolar illness and schizophrenia as oligogenic diseases: implications for the future
  • E. Gershon
  • Medicine, Psychology
  • Biological Psychiatry
  • 2000
As with most complex inheritance diseases, there are at this time no identified susceptibility genes for schizophrenia, bipolar manic-depressive illness, major depression, childhood autism, and otherExpand
Schizophrenia: Diverse Approaches to a Complex Disease
A brief overview of the parallel approaches being used to identify the molecular causes of schizophrenia is provided and possible directions for future research are discussed. Expand
Schizophrenia: genes and environment
  • M. Tsuang
  • Medicine, Psychology
  • Biological Psychiatry
  • 2000
The historical and genetic foundations of the current understanding of schizophrenia are reviewed, as are the present and future directions for research, and genetic and environmental components of the disorder are examined. Expand
The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?
This work has identified a number of candidate susceptibility loci/genes associated with inherited susceptibility to late-onset neurodegenerative diseases, schizophrenia, and bipolar disorder that are likely to interact with each other (and with nongenetic factors) to modulate susceptibility and/or disease phenotype. Expand
The genes for schizophrenia: Finally a breakthrough?
Though credible evidence is available for all of these genes, it is strongest for NRGI andDTNBPI, and further studies, particularly exhaustive analyses of all polymorphisms at each locus, meta-analyses, and investigations of the likely function of risk alleles (variants) are desirable. Expand
Genetic abnormalities of chromosome 22 and the development of psychosis
Although a number of genes have been implicated as possible schizophrenia susceptibility loci, further confirmatory studies are required, and compelling evidence that haploinsufficiency of TBX1 is likely to be responsible for many of the physical features associated with the deletion is provided. Expand
Molecular genetics of autism spectrum disorder
Recent studies in families with autism spectrum disorder have identified uncommon occurrences of a novel genetic syndrome caused by disruptions of the NLGN4 gene on chromosome Xp22, and the contributions of multiple approaches to identifying the genes of interest are highlighted. Expand
Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.
A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. Expand