Future chemoradiation strategies in pancreatic cancer.

@article{Crane2007FutureCS,
  title={Future chemoradiation strategies in pancreatic cancer.},
  author={Christopher H. Crane and Gauri R. Varadhachary and Peter W. T. Pisters and Douglas B. Evans and Robert A. Wolff},
  journal={Seminars in oncology},
  year={2007},
  volume={34 4},
  pages={335-46}
}
Although not universally accepted, 5-fluorouracil (5-FU)-based chemoradiation is considered a standard treatment for patients with localized pancreatic cancer. Randomized trials have indicated that chemoradiation improves median survival of both locally advanced and resected pancreatic cancer. While the use of adjuvant chemoradiation in pancreatic cancer has been called into question since the publication of the European Study Group for Pancreatic Cancer (ESPAC)-1 trial, this study has not… CONTINUE READING

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Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
All randomized trials investigating adjuvant chemoradiation have reported significant local as well as distant disease control limitations , making the study of novel chemoradiation and adjuvant chemotherapy important .
All randomized trials investigating adjuvant chemoradiation have reported significant local as well as distant disease control limitations , making the study of novel chemoradiation and adjuvant chemotherapy important .
All randomized trials investigating adjuvant chemoradiation have reported significant local as well as distant disease control limitations , making the study of novel chemoradiation and adjuvant chemotherapy important .
All randomized trials investigating adjuvant chemoradiation have reported significant local as well as distant disease control limitations , making the study of novel chemoradiation and adjuvant chemotherapy important .
Advantages of neoadjuvant chemoradiation compared to postoperative therapy include increased local control , increased access to therapy , addressing the systemic disease recurrence risk without delay , and optimal patient selection for pancreaticoduodenectomy through exclusion of patients with rapidly progressive metastatic disease .
Selected centers are investigating neoadjuvant chemoradiation in radiographically resectable patients .
Selected centers are investigating neoadjuvant chemoradiation in radiographically resectable patients .
Advantages of neoadjuvant chemoradiation compared to postoperative therapy include increased local control , increased access to therapy , addressing the systemic disease recurrence risk without delay , and optimal patient selection for pancreaticoduodenectomy through exclusion of patients with rapidly progressive metastatic disease .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
Recent strategies for improving the efficacy of chemoradiation include improved chemoradiation sensitization through the concurrent incorporation of molecular targeted agents , and the use of new radiation technology such as intensity - modulated radiotherapy ( IMRT ) and stereotactic radiotherapy .
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