In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism
Cardiovascular (CV) disease is the leading cause of death in women over the age of 50. Risk factors related to the increase in CV disease after transition into menopause include an increase in abdominal obesity, dyslipidemia, insulin resistance, and hypertension. Recent studies indicate that a history of preeclampsia increases future CV risk. Based on these findings, the National Institutes of Health sponsored a workshop in 2010 entitled, “Bridging Preeclampsia and Future Cardiovascular Disease.” The aims of the workshop were to “identify knowledge gaps and research opportunities” to facilitate the prevention of future CV risk in women who develop preeclampsia during pregnancy. Recommendations provided to the National Heart, Lung and Blood Institute from the workshop initiated with an aim to use “already established cohort studies.” It was suggested that studies or trials with well-defined diagnoses of preeclampsia could be used to prospectively follow patients long-term to assess CV outcome and to determine the progression of chronic disease.