Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.

@article{Coyne2014FutschMAP1BMI,
  title={Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.},
  author={Alyssa N. Coyne and Bhavani Bagevalu Siddegowda and Patricia S. Estes and Jeffrey S Johannesmeyer and Tina Kovalik and Scott G Daniel and Antony Pearson and Robert P. Bowser and Daniela C. Zarnescu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 48},
  pages={15962-74}
}
TDP-43 is an RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) that is known to regulate the splicing, transport, and storage of specific mRNAs into stress granules. Although TDP-43 has been shown to interact with translation factors, its role in protein synthesis remains unclear, and no in vivo translation targets have been reported to date. Here we provide evidence that TDP-43 associates with futsch mRNA in a complex and regulates its expression at the neuromuscular junction… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Cold Spring Harbor perspectives in medicine • 2017
View 2 Excerpts

Similar Papers

Loading similar papers…