Futile cycling increases sensitivity toward oxidative stress in Escherichia coli.

@article{Adolfsen2015FutileCI,
  title={Futile cycling increases sensitivity toward oxidative stress in Escherichia coli.},
  author={Kristin J. Adolfsen and Mark P. Brynildsen},
  journal={Metabolic engineering},
  year={2015},
  volume={29},
  pages={26-35}
}
Reactive oxygen species (ROS) are toxic molecules utilized by the immune system to combat invading pathogens. Recent evidence suggests that inefficiencies in ATP production or usage can lead to increased endogenous ROS production and sensitivity to oxidative stress in bacteria. With this as inspiration, and knowledge that ATP is required for a number of DNA repair mechanisms, we hypothesized that futile cycling would be an effective way to increase sensitivity to oxidative stress. We developed… CONTINUE READING