Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer

@article{Lin2010FusogenicMG,
  title={Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer},
  author={Edward H. Lin and Caroline Salon and Elisabeth Brambilla and Dimitri Lavillette and Judit Sz{\'e}csi and Francois Luic Cosset and Jean-Luc Coll},
  journal={Cancer Gene Therapy},
  year={2010},
  volume={17},
  pages={256-265}
}
Fusogenic membrane glycoproteins (FMGs) are viral envelope proteins, which bind surface receptors and induce fusion of the cell membrane. An FMG-transfected cell will fuse with neighbor cells, thus forming syncytia that die within 5 days. In this report, plasmids encoding for FMGs from Human Endogenous Retrovirus-W (HERV-W) was compared with Gibbon Ape Leukemia Virus (GALV) and feline endogenous virus RD-114 (RD). These plasmids were transfected in human non-small-cell lung cancer (NSCLC) cells… 
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