Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.

@article{Bateman2000FusogenicMG,
  title={Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.},
  author={Andrew Bateman and Frances Bullough and Susan Murphy and Lisa Emiliusen and Dimitri Lavillette and Francois Luic Cosset and Roberto Cattaneo and Stephen Russell and R G Vile},
  journal={Cancer research},
  year={2000},
  volume={60 6},
  pages={1492-7}
}
We report here the use of viral fusogenic membrane glycoproteins (FMGs) as a new class of therapeutic genes for the control of tumor growth. FMGs kill cells by fusing them into large multinucleated syncytia, which die by sequestration of cell nuclei and subsequent nuclear fusion by a mechanism that is nonapoptotic, as assessed by multiple criteria. Direct and bystander killing of three different FMGs were at least one log more potent than that of herpes simplex virus thymidine kinase or… CONTINUE READING

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Vector development for cancer gene therapy

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