Fusogenic activity of cationic lipids and lipid shape distribution

Abstract

Addition of co-lipids into cationic lipid formulations is considered as promoting cell delivery of DNA by enhancing fusion processes with cell membranes. Here, by combining FRET and confocal microscopy, we demonstrate that some cationic lipids do not require a co-lipid to fuse efficiently with cells. These cationic lipids are able to self-organize into… (More)
DOI: 10.1007/s00018-009-0197-x

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