• DOI:10.1016/j.chom.2013.07.007
Corpus ID: 20480859

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.

@article{Kostic2013FusobacteriumNP,
  title={Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.},
  author={Aleksandar D. Kostic and E. Chun and Lauren Robertson and J. Glickman and C. A. Gallini and M. Michaud and T. Clancy and D. Chung and P. Lochhead and G. Hold and E. El-Omar and D. Brenner and C. Fuchs and M. Meyerson and W. Garrett},
  journal={Cell host & microbe},
  year={2013},
  volume={14 2},
  pages={
          207-15
        }
}

• Aleksandar D. Kostic, E. Chun, +12 authors W. Garrett
• Published 2013
• Biology, Medicine
• Cell host & microbe

Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, but whether this is an indirect or causal link remains unclear. We find that Fusobacterium spp. are enriched in human colonic adenomas relative to surrounding tissues and in stool samples from colorectal adenoma and carcinoma patients compared to healthy subjects. Additionally, in the Apc(Min/+) mouse model of… Expand

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