Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.

@article{Kostic2013FusobacteriumNP,
  title={Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.},
  author={Aleksandar D. Kostic and E. Chun and Lauren Robertson and J. Glickman and C. A. Gallini and M. Michaud and T. Clancy and D. Chung and P. Lochhead and G. Hold and E. El-Omar and D. Brenner and C. Fuchs and M. Meyerson and W. Garrett},
  journal={Cell host & microbe},
  year={2013},
  volume={14 2},
  pages={
          207-15
        }
}
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, but whether this is an indirect or causal link remains unclear. We find that Fusobacterium spp. are enriched in human colonic adenomas relative to surrounding tissues and in stool samples from colorectal adenoma and carcinoma patients compared to healthy subjects. Additionally, in the Apc(Min/+) mouse model of… Expand
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Paper Mentions

Interventional Clinical Trial
The purpose of our study is to determine if an association exists between the microbiome of those with rectal adenocarcinoma who are complete pathologic responders and those who have a… Expand
ConditionsLocally Advanced Malignant Neoplasm, Rectal Cancer
InterventionProcedure
Observational Clinical Trial
It has been shown that gut microbiome and microbiome metabolism can regulate or control the initiation of a cancer process. To the best of the investigators knowledge, no study has… Expand
ConditionsMicrobiome, Papillary Thyroid Microcarcinoma
InterventionProcedure
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