Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.

  title={Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.},
  author={Kosuke Mima and Reiko Nishihara and Zhi Rong Qian and Yin Cao and Yasutaka Sukawa and Jonathan A. Nowak and Juhong Yang and Ruoxu Dou and Yohei Masugi and Mingyang Song and Aleksandar D. Kostic and Marios Giannakis and Susan Bullman and Danny Milner and Hideo Baba and Edward L. Giovannucci and Levi A. Garraway and Gordon J Freeman and Glenn Dranoff and Wendy S. Garrett and Curtis Huttenhower and Matthew L Meyerson and Jeffrey A. Meyerhardt and Andrew T. Chan and Charles S. Fuchs and Shuji Ogino},
  volume={65 12},
OBJECTIVE Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome. DESIGN We used molecular pathological epidemiology database of 1069 rectal and colon cancer cases in the Nurses' Health Study and the Health… CONTINUE READING