Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells.

@article{Arora1994FusionsOA,
  title={Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells.},
  author={Neeraj K. Arora and Stephen H Leppla},
  journal={Infection and immunity},
  year={1994},
  volume={62 11},
  pages={4955-61}
}
To investigate the ability of anthrax toxin lethal factor (LF) to translocate foreign proteins into the cytosol of eukaryotic cells and to characterize the structural requirements of this process, fusion proteins containing a portion of LF and the catalytic domains of either diphtheria toxin or Shiga toxin were constructed. Previous work showed that… CONTINUE READING