Fusion transcriptome profiling provides insights into alveolar rhabdomyosarcoma

  title={Fusion transcriptome profiling provides insights into alveolar rhabdomyosarcoma},
  author={Zhongqiu Xie and M. Babiceanu and S. Kumar and Yuemeng Jia and Fujun Qin and F. Barr and H. Li},
  journal={Proceedings of the National Academy of Sciences},
  pages={13126 - 13131}
  • Zhongqiu Xie, M. Babiceanu, +4 authors H. Li
  • Published 2016
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance Here, we propose an approach to study connections between biological samples. By using binary input of fusion RNA expression, samples of same or similar tissue origin were clustered together. The concept was then put into use to gain insights for the pediatric alveolar rhabdomyosarcoma (ARMS). We found that the signature fusion RNA for ARMS, PAX3–FOXO1 (paired box gene 3 fused with forkhead box O1), and all the other chimeric RNAs expressed in ARMS cells are expressed at the same… CONTINUE READING
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