Fusion to chicken C3d enhances the immunogenicity of the M2 protein of avian influenza virus

@inproceedings{Zhang2010FusionTC,
  title={Fusion to chicken C3d enhances the immunogenicity of the M2 protein of avian influenza virus},
  author={Zhenhua Zhang and Yongqing Li and Shufang Xu and Fuyong Chen and Li Zhang and Beiyu Jiang and Xiaoling Chen},
  booktitle={Virology Journal},
  year={2010}
}
Current vaccines to avian influenzae virus (AIV), a highly contagious disease of birds, need to be constantly updated due to the high level of variation in the target antigens. Therefore, a vaccine that could induce broad cross protection against AIV is required. The M2 membrane protein is structurally conserved amongst AIV subtypes but tends in induce a poor immune response, whereas C3d has been shown in many species to enhance immunogenicity. In this study, we investigated the potential of M2… CONTINUE READING

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