Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC.

@article{Schlke2010FusionPO,
  title={Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC.},
  author={Stefan Sch{\"u}lke and Zoe Waibler and Marc-Stefan Mende and Gianni Zoccatelli and Stefan Vieths and Masako Toda and Stephan Scheurer},
  journal={Molecular immunology},
  year={2010},
  volume={48 1-3},
  pages={341-50}
}
Toll-like receptor ligands are immune-modulatory components linking innate and adaptive immune responses and are considered to be promising vaccine components. Objective of this study was to investigate the adjuvant activity of Listeria monocytogenesis-derived TLR5-ligand flagellin A (flaA) genetically fused to ovalbumin (Ova, major chicken white egg allergen) in a murine in vitro system. Recombinant flaA, rOva, and a fusion protein of rflaA and rOva (rflaA:Ova) were over-expressed in… CONTINUE READING