Fusion protein linkers: property, design and functionality.

@article{Chen2013FusionPL,
  title={Fusion protein linkers: property, design and functionality.},
  author={Xiaoying Chen and Jennica L Zaro and W C Shen},
  journal={Advanced drug delivery reviews},
  year={2013},
  volume={65 10},
  pages={1357-69}
}
As an indispensable component of recombinant fusion proteins, linkers have shown increasing importance in the construction of stable, bioactive fusion proteins. This review covers the current knowledge of fusion protein linkers and summarizes examples for their design and application. The general properties of linkers derived from naturally-occurring multi-domain proteins can be considered as the foundation in linker design. Empirical linkers designed by researchers are generally classified… CONTINUE READING
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