Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

@article{Fioretos2001FusionOT,
  title={Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.},
  author={Thoas Fioretos and Ioannis Panagopoulos and Carin Lassen and Agneta Swedin and Rolf Billstr{\"o}m and Margareth Isaksson and Bodil Str{\"o}mbeck and Tor Olofsson and Felix Mitelman and Bertil Johansson},
  journal={Genes, chromosomes & cancer},
  year={2001},
  volume={32 4},
  pages={302-10}
}
Constitutive activation of tyrosine kinases as a consequence of chromosomal translocations, forming fusion genes, plays an important role in the development of hematologic malignancies, in particular, myeloproliferative syndromes (MPSs). In this respect, the t(9;22)(q34;q11) that results in the BCR/ABL fusion gene in chronic myeloid leukemia is one of the best-studied examples. The fibroblast growth factor receptor 1 (FGFR1) gene at 8p11 encodes a transmembrane receptor tyrosine kinase and is… CONTINUE READING
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