Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

@article{lvarezDolado2003FusionOB,
  title={Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes},
  author={Manuel {\'A}lvarez-Dolado and Ricardo Pardal and Jose Manuel Garc{\'i}a-Verdugo and John R. Fike and Hyun Ok Lee and Klaus Pfeffer and C Ndubuisi-Ogbonna Lois and Sean J Morrison and Arturo Alvarez-Buylla},
  journal={Nature},
  year={2003},
  volume={425},
  pages={968-973}
}
Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons1,2. Several groups have attributed this apparent plasticity to ‘transdifferentiation’3,4,5. Others, however, have suggested that cell fusion could explain these results6,7,8,9. Using a simple method based on Cre/lox recombination to detect cell fusion events, we demonstrate that bone-marrow-derived cells (BMDCs) fuse spontaneously with… CONTINUE READING
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