Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

  title={Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes},
  author={M. {\'A}lvarez-Dolado and R. Pardal and J. Garc{\'i}a-Verdugo and John R. Fike and H. Lee and K. Pfeffer and C. Lois and S. Morrison and A. Alvarez-Buylla},
  • M. Álvarez-Dolado, R. Pardal, +6 authors A. Alvarez-Buylla
  • Published 2003
  • Biology, Medicine
  • Nature
  • Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons. Several groups have attributed this apparent plasticity to ‘transdifferentiation’. Others, however, have suggested that cell fusion could explain these results. Using a simple method based on Cre/lox recombination to detect cell fusion events, we demonstrate that bone-marrow-derived cells (BMDCs) fuse spontaneously with neural… CONTINUE READING
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