Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling.

@article{Small2000FusionOB,
  title={Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling.},
  author={Kersten M Small and Siiri L Forbes and Fahema F Rahman and Stephen B. Liggett},
  journal={Biochemistry},
  year={2000},
  volume={39 10},
  pages={2815-21}
}
The forward and antegrade interactions that comprise the agonist receptor-G protein complex were studied in Chinese hamster fibroblasts transfected to express the beta(2)-adrenergic receptor (beta(2)AR), the beta(2)AR and the alpha-subunit of its cognate G protein (G(s)), and a protein consisting of the beta(2)AR fused at its carboxy terminus with G(alpha… CONTINUE READING