Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).

@article{Yagasaki1999FusionOT,
  title={Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).},
  author={Fumiharu Yagasaki and Itsuro Jinnai and Shinichiro Yoshida and Yasuko Yokoyama and Akira Matsuda and Shuya Kusumoto and Hirofumi Kobayashi and Hiroshi Terasaki and Kazuma Ohyashiki and Norio Asou and Ikuo Murohashi and Masami Bessho and Kunitake Hirashima},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={26 3},
  pages={192-202}
}
We identified a novel human long fatty acyl CoA synthetase 2 gene, ACS2, as a new ETV6 fusion partner gene in a recurrent t(5;12)(q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, and a patient with acute eosinophilic leukemia (AEL). ACS2 is expressed in the brain and bone marrow and is highly conserved in man and rats. The resulting ETV6/ACS2 fusion transcripts showed an out… CONTINUE READING

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