Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

@article{Crew1995FusionOS,
  title={Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.},
  author={A. Jayne Crew and Jeremy P. Clark and C Fisher and Sandra Gill and Robert J Grimer and Atish Chand and Janet Shipley and Barry Gusterson and Colin S Cooper},
  journal={The EMBO journal},
  year={1995},
  volume={14 10},
  pages={2333-40}
}
We demonstrate that the cytogenetically defined translocation t(X;18)(p11.2;q11.2) found in human synovial sarcoma results in the fusion of the chromosome 18 SYT gene to either of two distinct genes, SSX1 or SSX2, at Xp11.2. The SSX1 and SSX2 genes encode closely related proteins (81% identity) of 188 amino acids that are rich in charged amino acids. The N-terminal portion of each SSX protein exhibits homology to the Kruppel-associated box (KRAB), a transcriptional repressor domain previously… CONTINUE READING
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