Fusion of Cells by Flipped SNAREs

@article{Hu2003FusionOC,
  title={Fusion of Cells by Flipped SNAREs},
  author={Chuan Hu and Mahiuddin Ahmed and T. Melia and T. S{\"o}llner and T. Mayer and J. Rothman},
  journal={Science},
  year={2003},
  volume={300},
  pages={1745 - 1749}
}
The SNARE (soluble N-ethylmaleimide–sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t-SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes. 
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